Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis

Response to Letter Regarding Article, "Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study".

We thank Sardu and colleagues for their comments. Our report demonstrates that baseline levels of microRNA-30d (miR-30d) are correlated with response to cardiac resynchronization therapy and that miR-30d was dynamically regulated by mechanical stress. Moreover, miR-30d appeared to be an adaptive response and was cardioprotective against tumor necrosis factor-α–mediated apoptosis. Similar to our...

Circulating MicroRNA-30d Is Associated With Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study.

BACKGROUND Biomarkers that predict response to cardiac resynchronization therapy (CRT) in heart failure patients with dyssynchrony (HFDYS) would be clinically important. Circulating extracellular microRNAs (miRNAs) have emerged as novel biomarkers that may also play important functional roles, but their relevance as markers for CRT response has not been examined. METHODS AND RESULTS Comprehen...

Great Expectations: MicroRNA-30d and Cardiac Resynchronization Therapy.

The broken heart. You think you will die, but you just keep living, day after day after terrible day. 1 T here seem to be as many approaches to managing heart failure as there are causal factors. Heart failure management is evolving from a one-size-fits-all approach centered around therapy with neurohormonal antagonists toward strategies tailored to provide the optimal clinical benefit based on...

Great Expectations: MicroRNA-30d and Cardiac Resynchronization Therapy Running title: Dorn; miR-30d as a biomarker for resynchronization success

Late best response to cardiac resynchronization therapy is associated with better survival of patients with congestive heart failure

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